STAT3 acts by directly and indirectly regulating the expression of the maintenance methyltransferase DNMT1 and by directing all three major methyltransferases (DNMT1, DNMT3A, and DNMT3B) to STAT3 binding sites within promoters of genes such as SHP1 or IL2RG. The role of STAT3 as a mediator of DNA methylation of target promoters was supported by recent data, demonstrating a function of acetylated STAT3 for inducing the methylation of tumor suppressor genes in melanoma and breast cancer (5). This evidence concerns the gene DNMT1 and melanoma.