Therefore, we compared DMRs, defined over 1-kb tiling windows, between ALK tumor cells and Ctrl thymocytes to ENCODE ChIP-seq datasets for active enhancers including monomethylation of histone H3 lysine K4 (H3K4me1) and acetylation of histone H3 lysine 27 (H3K27ac) in murine thymi (74, 75). Here, ALK is linked to neoplasm.