ALK and cancer: These include the suppressor of cytokine signaling 3 (Socs3), which is a regulator of the JAK/STAT signaling pathway and was also found up-regulated in human ALK+ ALCL cell lines (54), tripartite motif containing 66 (Trim66), which is part of the rat sarcoma (RAS) pathway that regulates DNMT1 expression and is known to promote proliferation (55, 56, 57) and granzyme A (Gzma) a canonical cytotoxic gene that is involved in cancer initiation and progression (58) (Fig 5D).