Furthermore, genes that showed higher expression patterns in ALK tumors compared with the simulated mixture were associated with cancer development, progression and aggressiveness, such as Tbx19, Nwd1, Sytl2, Amigo2, and Dpp4. Genes that were associated with Notch signaling (Nrarp and Dtx1) were also strongly induced in ALK tumors compared with the simulated ALK sample (Table S4). This evidence concerns the gene SYTL2 and cancer.