Potentially targeting FVIII/FIX:C, >10%–150% of normal postgene transfer is supported by both the aforementioned prothrombotic risks associated with supraphysiologic FVIII/FIX:C206, 207, 208 and available HA natural history data that demonstrate that FVIII:C of ≥12% of normal (by OSA) is adequate to prevent spontaneous joint bleeding.210. Here, F8 is linked to obstructive sleep apnea syndrome.