LRRK2 and Parkinson disease: Another study, also using hiPSCs derived from PD LRRK2-positive patients, reported astrocyte-specific downregulation of genes associated with inhibition of microglial inflammatory responses and α-synuclein aggregate degradation (Booth et al., 2019), importantly implicating the loss of astrocyte neuroprotective capacity as a key player in the development of PD pathology.