They found that pT487-EZH2 inhibits H3K27me3 by decreasing EZH2 methyltransferase activity and attenuating EZH2 associated with other PRC2 subunits, thereby derepressing EZH2 target gene transcriptional silencing and inhibiting cells invasion and metastasis in breast cancer cells and human mesenchymal stem cells. The gene discussed is EZH2; the disease is breast cancer.