EZH2 and breast cancer: It means that OGT-mediated EZH2-GlcNAcylation have several different functions in breast cancer progression. Acetylation is a reversible and important PTM that regulates a series of cellular processes, including proliferation, apoptosis, migration, and metabolism, in cancer cells; it is achieved through the modulation of core histones or non-histone proteins by histone acetyltransferases (HATs) or histone deacetylases (HDACs) [60–66].