Finally, it was interesting to observe that the mean 13C labeling of aspartate derived from [13C5]-glutamine anaplerosis into the TCA cycle was significantly higher in both CD138+ pre-malignant and malignant plasma cells from MGUS and MM patients, respectively, when compared to the remainder of their paired CD138- mononuclear cells. This evidence concerns the gene SDC1 and Miyoshi myopathy.