While the glutamine anaplerosis into the TCA cycle based on the mean 13C labeling of the TCA metabolites was higher in malignant compared to pre-malignant CD138+ bone marrow plasma cells relative to the remainder of their paired CD138- bone marrow mononuclear cells (Fig. 2b), this was heterogeneously observed among individual MGUS and MM patients (Fig. 2c). The gene discussed is SDC1; the disease is Miyoshi myopathy.