Further, we constructed additional 4 groups of nude mouse models with subcutaneous tumors that were circCDKN2B-AS1 overexpressed or not, and found that circCDKN2B-AS1 overexpression promoted tumor growth (Fig. 6f)), elevated LA and PA contents (Fig. 6g), elevated the level of HK2 mRNA expression of in tumor tissues with a positive correlation between them (Fig. 6h), and facilitated recruitment rate of HK2 mRNA 3’UTR to IMP3 (Fig. 6i, Additional file 11: Fig. S6). The gene discussed is IMP3; the disease is neoplasm.