Additionally, there was a significant positive correlation between the expression of circCDKN2B-AS1 and HK2 mRNA in xenografted tumors regardless circCDKN2B-AS1 knockdown or overexpression, suggesting that circCDKN2B-AS1 facilitates cellular malignant phenotypes of cervical cancer via interacting with IMP3 and HK2 mRNA in vivo. This evidence concerns the gene HK2 and cervical carcinoma.