We constructed nude mouse models to observe circCDKN2B-AS1 effect on aerobic glycolysis and progression of cervical cancer, and found that the growth of xenografted tumors was markedly retarded (Fig. 6a) and the levels of both HK2 mRNA and protein expression were lower, with a significantly positive correlation between HK2 mRNA and circCDKN2B-AS1 expression (Fig. 6b-c), in 6 pairs of nude mice with depletion of circCDKN2B-AS1 compared to controls. This evidence concerns the gene HK2 and cervical carcinoma.