SMARCA2 and intellectual disability-sparse hair-brachydactyly syndrome: Lastly, we also estimated that SMARCA2 has a strong predictive effect on and a nominally positive association with IQ; previous literature shows that epigenomic effects on and genetic dysfunction of SMARCA2 plays a role in development of Nicolaides-Baraitser syndrome, a developmental disorder categorized by intellectual disability and seizures [68, 69].