RANGAP1 and gastric cancer: For example, Lu’s study demonstrated that circ-RanGAP1 was significantly upregulated in both GC tissues and exosomes from the plasma of GC patients and high circ-RanGAP1 expression was closely associated with an advanced TNM stage and worse survival, which suggest that circ-RanGAP1 might act as a potential prognostic biomarker [36].