MCL1 and cancer: For instance, b-carboline copper(II) complexes were described as MCL-1 inhibitors that act in a BAX/BAK dependent manner and show potent anti-tumor activity in preclinical cancer models that was even superior as compared to the activity of AZD5991 (57% vs 23% tumor growth inhibition at 10 mg per kg in NCI-H460 tumor cell xenografts) [149].