Gupta et al. were able to demonstrate that IL-6 alters the phosphorylation status of BIM in myeloma cells and thereby promotes the formation of MCL-1:BIM complexes (which outcompetes BCL-2 or BCL-xL binding to BIM) at least in part in a MEK signaling-dependent manner [95]. The gene discussed is BCL2; the disease is plasma cell myeloma.