In some studies, the application of a monoclonal antibody specific for RANKL was demonstrated to be effective in ameliorating alveolar bone destruction in experimental periodontitis and LPS-induced calvarial bone damage in a mouse model; the coverage of osteoclasts in calvaria was greatly diminished, and the amount of resorption pits caused by osteoclasts was significantly reduced compared to that in the control group [43]. This evidence concerns the gene TNFSF11 and periodontitis.