The results showed that tumor differentiation (moderate vs. poor: OR = 0.23, 95% CI: 0.03–0.99, p = 0.05), discordance of the density of CD8 between primary tumors and liver metastases (yes vs. no: OR = 8.95, 95% CI: 2.06–39.00, p = 0.004) were associated with obvious discordance of PD-L1 expression between primary tumors and liver metastases. This evidence concerns the gene CD274 and neoplasm.