According to Table 1, 41 out of 74 patients (55%) were positive for PD-L1 expression in liver metastases; The rate of PD-L1 positivity in rectal cancer liver metastases was higher than in colon cancer liver metastases (positivity rate:70.6% vs. 42.5%); The expression of PD-L1 in liver metastases was related to the density of CD4 and CD8 which were higher in PD-L1 positive patients (Fig. 1). This evidence concerns the gene CD4 and malignant colon neoplasm.