The PPI network consisted of 8 gene products for the following genes: GATA4, ID2, MAFA, NOX4, PTBP1, SMAD3, TUBB1, and WWOX. We conducted a literature search in PubMed to investigate the potential associations between those 8 genes/proteins and pulmonary or cardiac diseases. The gene discussed is TUBB1; the disease is heart disorder.