As shown in Additional file 4: Fig. S4e, the relatively specific lincRNA RP11-65L19.4 gene mutation in the ectoderm group occurred only in four breast cancer cases and two skin cancer cases; PPP1R2P9 AP00345.1 and C16orf95 genes in the mesoderm group mainly existed in the cases with uterus tumors. The gene discussed is C16orf95; the disease is breast cancer.