Previous studies have found that the expression of SERCA in hepatocytes and macrophages of obese mice is decreased with IR, and the expression of ERS signaling molecules is upregulated, but recovery of SERCA2 can alleviate ERS, normalize content of blood glucose and hepatic TG, and even facilitate transduction of insulin [59].In addition, activity of SERCA2 protein of islet β cells in diabetic patients were decreased through NO−/AMPK-dependent pathways under inflammatory response, which could result in glucose intolerance and reduce islet β cell proliferation and insulin secretion. Here, ATP2A2 is linked to Glucose intolerance.