Increases of 39.0% in hs-CRP, 228.5% in PCT, 28.5% in PUA, and 34.0% in PUN, and decreases of 26.3% in monocyte percentage, 6.7% in antithrombin III, 15.8% in HDL-C, 17.0% in non-HDL-C, 13.0% in apolipoprotein A1, 14.8% in apolipoprotein B, and 38.7% in eGFR, indicated an increasing risk of death in COVID-19 patients. The gene discussed is SERPINC1; the disease is COVID-19.