PKD2 and autosomal dominant polycystic kidney disease: While the exact pathological roles of these proteins are still debated but it is clear that cystogenesis in ADPKD takes place when both the copies of either PKD 1 or PKD2 gets mutated and cause the defect in the primary cilia owing to the change in the genetic expression of aforementioned genes (Cornec-Le et al. 2019; Harris 2010).