GLI1 and autosomal dominant polycystic kidney disease: They also found that when the THM1 conditional knockout mice (THM1 cko) and GLI2−/− mice were treated with Gant61 (a GLI antagonist) in the presence of 8-Br-cAMP; milder cystic growth was seen in (THM1 cko + GLI2−/−) mice as compared to THM1 cko, thus suggesting the role of Hh pathway in renal cystogenesis in ADPKD (Tran et al. 2014).