PPARG and type 2 diabetes mellitus: The activation of PPAR-gamma leads to various actions that consequently leads to the actions that include transactivation of the genes that regulate the adipocyte differentiation that leads to an increased number of small insulin-sensitive adipocytes, increased uptake of glucose by skeletal muscle, and decreased production of glucose by the liver which consequently are responsible for its glucose-lowering effect in type-2 diabetes mellitus patients; thereby decreasing the insulin resistance (Iglesias and Díez 2006; Tyagi et al. 2011).