reported that in PCK−/−-AVP−/− rat, which was formed by crossing the PKD1 deficient; PCK−/−, and Brattleboro AVP−/− rat, treatment with 1-deamino-8-d-arginine vasopressin (V2R agonist) increased the level of renal cAMP and had an increased cyst volume. This evidence concerns the gene PKD1 and cyst.