PKD1 and autosomal dominant polycystic kidney disease: Now, how the polycystin-1 relates to the development of ADPKD can be sought from the study of Sutters et al. who conducted their study to find the effect of overexpression of C-terminal of polycystin-1 on the cAMP-responsive cell proliferation of M-1 cells (a cell that retains the characteristic of cells of collecting duct).