reported that cAMP-mediated cystogenic potential of tetratricopeptide repeat-containing hedgehog modulator-1 (THM1); a protein whose deficiency has been found to cause the renal cysts, got reduced when GLI2 (a transcription activator of Hh pathway) was genetically deleted in a mouse model of ADPKD. This evidence concerns the gene TTC21B and cystic kidney disease.