Due to the defect in polycystin-2 (calcium channel) in ADPKD, there is a decreased intracellular calcium and this could not activate the PI3K, therefore an unfortunate activation of Raf takes place that ultimately is accountable for the cell proliferation via Ras/Raf/MEK/ERK pathway (Li et al. 2016). The gene discussed is MAP2K7; the disease is autosomal dominant polycystic kidney disease.