They also found that when the THM1 conditional knockout mice (THM1 cko) and GLI2−/− mice were treated with Gant61 (a GLI antagonist) in the presence of 8-Br-cAMP; milder cystic growth was seen in (THM1 cko + GLI2−/−) mice as compared to THM1 cko, thus suggesting the role of Hh pathway in renal cystogenesis in ADPKD (Tran et al. 2014). Here, TTC21B is linked to autosomal dominant polycystic kidney disease.