WMH in a cluster located in theintersection between the anterior limb of the internal and external capsulesin the left hemisphere’s corticopontine white matter tract had strongernegative association with hypertension, total cholesterol, homocysteine andanticardiolipin IgG and IgM and with markers of clinical disease than in therest of the locations where associations were found. This evidence concerns the gene CD40LG and hypertensive disorder.