Alternative strategies aiming at improving glycemic control in the first weeks of life by stimulating endogenous insulin secretion, such as early provision of sufficient protein intake [39–41] and early enteral feeding [41,42], as well as preventing hypophosphatemia—which is associated with an increased risk of hyperglycemia [43]—may be interesting to explore, possibly in an integrated approach to prevention. Here, INS is linked to hypophosphatemia.