However, the levels of pMLC (phosphorylated MLC), which is crucial for the structural actin cytoskeleton stability, were only increased in the ACC, and its expression in the DFC remained unchanged, suggesting that the PAK1 downstream pathways are distinguishingly affected in the cortical regions of patients with schizophrenia (Rubio et al., 2012). This evidence concerns the gene PAK1 and schizophrenia.