MAPT and proteostasis deficiencies: The in vivo findings of this cross-sectional study suggest that the phenomenon of super aging may be associated with higher brain resistance against the buildup of both tau tangles and amyloid-β plaques, which could prevent neurodegeneration, as previously hypothesized.1,3 Normal aging, in contrast, appears to be associated with tau tangles but not amyloid plaques, pointing to a role of isolated tau accumulation in age-related cognitive decline, whereas synergistic effects of both proteinopathies seem to accelerate the unsuccessful aging process as seen in MCI.