Intriguingly, ablation of CK1α from murine skin keratinocytes resulted in epidermal hyperpigmentation in the footpads, resembling phenotypes observed in the palms and soles of human patients with palmoplantar keratoderma resulting from FAM83G mutations [64,81,82]. The gene discussed is CSNK1A1; the disease is Palmoplantar keratoderma.