Critical unanswered questions are whether NLRP3 inflammasome activation in RPE cells or in non-RPE cells (e.g. macrophages or retinal microglia) promotes AMD pathologies and whether the inflammasome can be activated in AMD not only through NLRP3-dependent but also through NLRP3-independent mechanisms. Here, NLRP3 is linked to age-related macular degeneration.