TARDBP and Motor neuron atrophy: Of note, several previous studies showed that the loss of liver X receptor β (LXRβ), a mammalian ortholog of EcR, results in motor neuron degeneration (Andersson et al., 2005; Bigini et al., 2010) and that LXRβ physically interacts with TDP-43 (Vanden Broeck et al., 2013).