In conclusion, this study demonstrated that SPT6 promoted CRC progression by transcriptionally activating hTERT, and such transcriptional activation needed the involvement of SND1, which functionalizes as the synergistic transcriptional factor to co‐anchor at the hTERT promoter region (−234 to −144) with SPT6 to co‐regulate hTERT expression and the sequential CRC progression. Here, SUPT6H is linked to colorectal carcinoma.