Besides, SND1 knockdown reversed the changes of the transcriptional activity of hTERT, the expression of hTERT, cell viability, tumorsphere‐forming ability and the expression of stemness‐associated markers in colon cancer cells mediated by SPT6 overexpression, and vice versa (Fig. 5E–I). This evidence concerns the gene SUPT6H and malignant colon neoplasm.