Besides, SND1 knockdown reversed the changes of the transcriptional activity of hTERT, the expression of hTERT, cell viability, tumorsphere‐forming ability and the expression of stemness‐associated markers in colon cancer cells mediated by SPT6 overexpression, and vice versa (Fig. 5E–I). The gene discussed is SUPT6H; the disease is colonic neoplasm.