SND1 and neoplasm: Given the complexity of the transcription mechanism in the tumor [39, 40], the broad interaction of SPT6 with other proteins in the maintenance of chromatin structure, and the possibility that SPT6 binds to hTERT promoter indirectly, we proposed the existence of the synergistic factors for SPT6 in initiating hTERT transcription and further identified SND1 as such synergy factor targeting hTERT through the binding at the promoter of hTERT.