Consistently, recent histopathological case studies from post-mortem COVID-19 patient tissues have reported the reactivity of SARS-CoV2 spike protein antibody in tracheal submucosa lymphocytes and alveolar macrophages [30], with observations of the splenic and lymph node regions of severe COVID patients have shown significant lymphocytic apoptosis, and SARS-CoV2 nucleoprotein reactivity along with IL-6 upregulation in ACE2 positive macrophages [31]. This evidence concerns the gene ACE2 and COVID-19.