RPS6KA1 and neoplasm: These data suggest that FMK-MEA at the dose of 20 mg/kg/day is unable to inhibit the activation of p90RSK in tumor cells (Figures 8C,G) but is able to prevent the activation of p90RSK in the tumor vessels, and that p90RSK activation is crucial in the regulation of tumor vasculature hyper-permeability.