In cultured oligodendrocytes from Twitcher mice (galctwi/twi), naturally occurring murine model for Krabbe disease, and patient fibroblasts with nonsense mutations in GALC gene, the nonsense-mediated mRNA decay (NMD) inhibitor 1 (NMDI1) (Durand et al., 2007) increased the levels of mRNA and rescued galactocerebrosidase (GALC) activity in a dose-dependent manner, and improve the morphology of the differentiated oligodendrocytes (Luddi et al., 2016). This evidence concerns the gene GALC and Krabbe disease.