The phosphorylated Tyr951 (pY951) site at the TKD of VEGFR-2 can bind T-cell-specific adapter (TSAd) in the vascular endothelial cells of tumor tissue (Matsumoto et al., 2005), activate formation of TSAd and Src complex, and subsequently regulate cell migration. This evidence concerns the gene SH2D2A and neoplasm.