KDR and neoplasm: VEGF-activated VEGFR-2 mediate the phosphorylation of many proteins in the downstream signaling pathways, e.g., Akt (protein kinase B), mTOR (mammalian target of rapamycin), Erk1/2 (extracellular signal-regulated kinase 1/2), FAK (focal adhesion kinase), and p70S6K (ribosomal protein S6 kinase), and promotes tumor angiogenesis (Karar and Maity, 2011; Lechertier and Hodivala-Dilke, 2012; Ji et al., 2018).