KDR and cancer: The VEGFA/VEGFR-2 signal transduction leads to endothelial cell proliferation, migration, survival and new vessel formation involved in angiogenesis, and has been implicated in pathogenesis of several diseases, e.g., inflammation, cancers, ophthalmic diseases, and neurological diseases (Louveau et al., 2015; Ferrara and Adamis, 2016; Ma et al., 2017).