Thereafter, to further elucidate the effect of miR-320a/HIF1α/KDM5B/PTEN axis on radioresistance of NSCLC xenografts in vivo, BALB/c nude mice were treated with lentiviral vector (Lv)-oe-NC + Lv-sh-NC + 10 Gy, Lv-oe-miR-320a + Lv-sh-NC + 10 Gy, and Lv-oe-miR-320a + Lv-sh-PTEN + 10 Gy. Here, KDM5B is linked to non-small cell lung carcinoma.