Wan et al. (2015) observed that miR-320a upregulation led to the suppression of the colon cancer cell proliferation and migration, resulting in hypersensitivity to chemoradiotherapy. Intriguingly, our study illustrated the targeting relationship between miR-320a and HIF1α in NSCLC and identified HIF1α as a target gene of miR-320a. In retinoblastoma, it has been reported that miR-320 suppressed autophagy by targeting HIF1α under hypoxic conditions, which was consistent with our findings (Liang et al., 2017). The gene discussed is HIF1A; the disease is colonic neoplasm.