The transcriptome analysis showed considerable downregulation of the enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) and mTOR signaling pathway in trophoblasts treated with treated with AD-MSC-derived exosomes; mTOR was putatively recognized as an upstream inhibitor of autophagy under hypoxic conditions. This evidence concerns the gene EZH2 and Alzheimer disease.