Out of the seven cases that showed discordance of both MTAP and CDKN2A between ddPCR and FISH, four cases (190049, 190080, 190088, 190092) were attributed to be because of tumor heterogeneity, two cases (190089 and 190093) were marginal ddPCR threshold and one case (190042) was marginal FISH threshold. This evidence concerns the gene CDKN2A and neoplasm.