CHRNB4 was also associated with long noncoding RNA, such as DHRS4-AS1, DHRS4L2, DHRS4L1, and SMAD5-AS1, which functions by affecting the proliferation, invasion (epithelial-mesenchymal transition), cell cycle progression and the apoptosis of cancer cells (42, 43). The gene discussed is DHRS4L1; the disease is cancer.