However, a meta-analysis of clinical exercise studies have shown that muscle-strengthening exercise enhances cardiometabolic (e.g. improved glucose/lipid metabolism, insulin sensitivity, blood pressure) (Ashton et al., 2018), mental (e.g. reducing symptoms of anxiety/depression) (Gordon et al., 2018, Gordon et al., 2017) and functional health-related outcomes (e.g. enhanced mobility/muscle strength) (Liu, 2009), all of which are likely to be beneficial for sleep quality (Grandner, 2017). The gene discussed is INS; the disease is major depressive disorder.