By analyzing RNA‐Seq dataset GSE60188,[16] we also found that Bscl2 is down‐regulated when Prmt5 is perturbed.[24] In addition, our Prmt5AKO mice phenocopied the Bscl2 knockout mice in lipodystrophy.[25] The Bscl2 gene encodes Seipin, a critical regulator of LD biogenesis following TAGs biosynthesis in the space between inner and outer membranes of ER (Figure 5b). Here, PRMT5 is linked to lipodystrophy.