A study following up 2625 T2D participants for over 10 years showed that 12% diabetic patients with normal body weight have almost twice higher overall mortality rate.[50] We found that PRMT5 expression in WAT is positively correlated with the body weight status in T2D patients by analyzing a published dataset.[21] In our mouse model, especially after HFD treatment, Prmt5 deficiency also leads to a lean but more diabetic phenotype. The gene discussed is PRMT5; the disease is type 2 diabetes mellitus.