HMGB1 and neoplasm: Compared to treatment with OxPt or DHA alone, the tumor cells treated with OxPt/DHA exhibited significantly greater ICD, as demonstrated by the increased ratio of CRT expression on the tumor surface and increased release of HMGB1 (Figure 2b,c).[70] This core–shell nanoplatform induced long‐lasting antitumor immunity by stimulating both innate and adaptive immune response, and its antitumor efficacy was magnified by combination with α‐PD‐L1 (Figure 2d).[71]