CD47 and neoplasm: Many tumor cells overexpress immune checkpoint CD47,[138] a membrane‐bound protein that prevents phagocytosis of tumor cells by DCs and macrophages.[139] Mice treated with the prodrug vesicles and αCD47 had less tumor microenvironment immunosuppression as indicated by decreased proliferation of Treg cells and increased tumor‐infiltrating CTLs, leading to less tumor metastasis and tumor recurrence.[137]