STING1 and cancer: In addition, cGAS is a well‐studied DNA‐binding protein, which can produce cGAMP, a second messenger, to activate downstream adaptor molecule STING.[21] Besides its main function in eliciting effective immunoreaction against microbial pathogens, STING signaling also plays an important role in various cell types, such as cardiomyocytes,[22, 23] intestinal epithelium,[24] and cancer cell.[15, 25] However, the role of STING signaling in NPCs during brain development has never been reported.