Shu et al. constructed multifunctional RNA NPs using the three‐way junction motif, thus manipulating the properties of RNA for targeted imaging and therapy of triple negative breast cancer.[77] To precisely guide the anti‐miRNAs to the cancerous cells, epidermal growth factor receptor (EGFR) aptamers were used as targeting ligands to internalize the RNA NPs into cancer cells via receptor‐mediated endocytosis and then imaged using the fluorescent agent, Alexa674. Here, EGFR is linked to triple-negative breast carcinoma.