Excitingly, the NPs crossed the blood–brain barrier (BBB) to accumulate throughout the tumor mass in GBM mouse models (Figure10).[96a] The NPs were designed to target the oncoprotein Bcl2Like12 (Bcl2L12), an effector caspase, and p53 inhibitor overexpressed in GBM relative to a healthy brain. The gene discussed is BCL2L12; the disease is glioblastoma.