TP53 and neoplasm: designed a DNA‐based co‐delivery system which contained a linear tumor therapeutic gene (p53) and DOX for the combined therapy of MDR tumor (MCF‐7R) using a MUC1 aptamer‐mediated targeted delivery.[85] The structure, which resembles a kite (“nanokite”), exhibited superior anticancer activity against MCF‐7R both in vitro and in vivo.