NT-proBNP: N-terminal pro-B-type natriuretic peptide, DM: diabetes mellitus; HTN: hypertension; IHD: ischemic heart disease; COPD: chronic obstructive pulmonary disease, CA: carcinoma, CBD: common bile duct, GIST: gastrointestinal stromal tumor, APR: abdominoperineal resection. The gene discussed is NPPB; the disease is diabetes mellitus.