For further verification, we evaluated the prognostic value of YTHDC2 in HNSCC using Kaplan–Meier plotter database, and we found that low expression of YTHDC2 was also associated with poor overall survival (OS) and recurrence-free survival (RFS) (OS HR = 0.65, 95% CI [0.48–0.89], P = 0.0065; RFS HR = 2.57, 95% CI [1.21–5.48], P = 0.011) (Figs. 4B and 4C). This evidence concerns the gene YTHDC2 and head and neck squamous cell carcinoma.