In this study, we found STAT1 of Th1 cells, STAT6 of Th2 cells, BCL6 of Tfh cells, STAT3 of Th17 cells, FOXP3, CCR8, CD25 (IL-2R) and STAT5B of Tregs, IRF4 of Th9 cells, FOXO4,CD196 (CCR6) and CD194 (CCR4) of Th22 cells are significantly correlated with YTHDC2 expression in HNSCC. This evidence concerns the gene STAT5B and head and neck squamous cell carcinoma.