In addition, the involvement of TLR2 and TLR4 for host defense against cryptococcosis has been studied in relation to Cryptococcus neoformans infection, for which there is no consensus regarding the contributions of TLR2 and TLR4 to immunity response during the establishment of C. neoformans infection (Biondo et al., 2005; Nakamura et al., 2006; Yauch et al., 2004). The gene discussed is TLR4; the disease is cryptococcosis.