They likely are derived from the over blow innate immune cell response of the over stimulated macrophage family of Mac 1‐type subsets stimulated by TNF‐α, and subsequently still during active infection by the viral antigen activated Th1 cell and Th17 T cell‐derived cytokines; respectively INF‐γ and IL‐17 stimulated donor cells. This evidence concerns the gene TNF and infection.