EGFR and nasopharyngeal carcinoma: In summary, our study is the first to reveal that EGFR‐rich EVs derived from highly metastatic NPC cells induce the up‐regulation of EGFR and reduce intracellular ROS levels through the EGFR/PI3K/AKT axis to promote the metastasis of poorly metastatic NPC cells, aggravating the progression of NPC.