Activation of the EGFR/PI3K/AKT axis is related to the metastasis of lung adenocarcinoma, intrahepatic cholangiocarcinoma, and hepatocellular carcinoma (Hu, Chen, Lou, Zhang, & Yang, 2020; Tiemin et al., 2020; Zhangyuan et al., 2020). This evidence concerns the gene AKT1 and intrahepatic cholangiocarcinoma.