As we have shown, H‐EVs uptake can promote the metastasis of low metastatic NPC cells and H‐EVs‐mediated EGFR up‐regulation can reduce the intracellular ROS level of low metastatic NPC cells through the PI3K/AKT pathway, we therefore sought to investigate the association between tumour metastasis and EGFR‐induced ROS reduction. The gene discussed is EGFR; the disease is nasopharyngeal carcinoma.