To investigate the detailed mechanism by which EGFR‐enriched H‐EVs internalization promotes low metastatic NPC cells metastasis, we co‐cultured H‐EVs with NPC cells, and found that H‐EVs internalization up‐regulated the expression of EGFR in 6–10B and S26 cells, reaching the expression levels of EGFR in 5–8F and S18, respectively (Figure 4a). The gene discussed is EGFR; the disease is nasopharyngeal carcinoma.