To further explore the role of EVs‐mediated communication for NPC metastasis, we demonstrated that H‐EVs‐mediated EGFR overexpression down‐regulates ROS levels through PI3K/AKT signalling, thus promoting the low metastatic potential NPC cells to the same degree of metastasis as highly metastatic NPC cells (Figure 3 and Figure 5). The gene discussed is EGFR; the disease is nasopharyngeal carcinoma.