Mukherjee et al. (2019) reported that Tyrobp and Fcer1g were among the hub genes in the gene network strongly associated with both aging and neurodegenerative diseases. A marked change observed in aging is also related to the composition and functionality of CD4+ T cells, the commander of adaptive immune responses. The dynamic reorganization of CD4+ T cell subsets were promoted by aging, in which activated regulatory T cells overexpressing Cd74 and other markers were identified (Elyahu et al., 2019). The gene discussed is CD74; the disease is neurodegenerative disease.