TP53 and colorectal carcinoma: A recent study by our group characterized the CRC in the Brazilian population, showing high prevalence in the APC (71.4%), TP53 (56.0%), KRAS (52.7%), PIK3CA (15.4%), and FBXW7 (10.9%) gene drivers, together with alterations in the MAPK/ERK, PIK3/AKT, NOTCH, and receptor tyrosine kinase signaling pathways (Dos Santos et al., 2019).