In 2017, Li et al. found that FTO enhanced leukemia oncogene-mediated cell transformation and leukemogenesis and inhibited all-trans-retinoic acid (ATRA)-induced AML cell differentiation by affecting the expression of targets mRNAs such as ASB2 and RARA, through reducing the level of m6A (Li et al., 2017). The gene discussed is RARA; the disease is acute myeloid leukemia.