YTHDF2 and obesity due to melanocortin 4 receptor deficiency: Furthermore, Wu et al. found that FTO regulated adipogenesis by dominating cell cycle proteins such as CCNA2 and CDK2 by m6A-YTHDF2 dependent pathway, revealing a new mechanism about anti-obesity and anti-adipogenesis activity of Epigallocatechin gallate (EGCG) (Wu et al., 2018a,b).