Moreover, the response rates to the immune checkpoint blockade (ICB); anti-PD-1/anti-CTLA-4 in breast cancer was found to have a direct correlation with the extent of tumor immune infiltrate, which is correlated with upregulated macrophages derived CXCR3 ligands, CXCL9, and CXCL10 (38). This evidence concerns the gene CXCL9 and breast cancer.