IFNG and neoplasm: Indeed, chemokine CXCL9 is induced by IFN-γ to mediate lymphocytic infiltration to the focal sites thus suppressing tumor growth (35), in addition, CXCL9 was found to be significantly associated with increased pathologic complete response rate (pCR) in breast cancer (36) and prolonged disease-free and overall survival in patients with the triple-negative disease (37).