Molecular studies in SI-NEN cell lines (KRJ-I, H-STS) showed increased activation of AKT respective to normal Enterochromaffin (EC) cells that exhibited inferior expression of transcripts for AKT and mTORC1 as well as a lower level of Akt activation suggesting a neoplasia-related involvement of this pathway (32). This evidence concerns the gene AKT1 and neoplasm.