In fact, increasing tau O-GlcNAcylation via inhibition of O-GlcNAcase in JNPL3 tauopathy mouse model [mutant tau P301L under the mouse PRNP promoter (95)] hindered tau aggregation and decreased neuronal cell loss by impairing tau's ability to oligomerize and without affecting tau phosphorylation (96). The gene discussed is PRNP; the disease is tauopathy.