Thus, the concept of liquid-liquid phase separation (LLPS) of proteins arising from curiosity-driven insights into the why's and wherefore's of low complexity domains in proteins has been extended to encompass DNA-binding protein 43 (TDP-43), heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) and fused in sarcoma (FUS) in neurodegenerative diseases and now tau itself. The gene discussed is MAPT; the disease is neurodegenerative disease.