Given that thorn-shaped tau inclusions at astrocytic end-feet are hallmarks in both PSP and ARTAG (166, 173), these data may suggest an intriguing connection (or competition) between pathologic spread of toxic tau conformers vs. inactivation of proteinaceous pathological tau seeds (Figure 4) (184, 207). Here, MAPT is linked to supranuclear palsy, progressive, 1.