The proinflammatory state induced by the cytokine storm is characterized mainly by the dysregulated production of cytokines, such as interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-α, that can trigger the development of virus induced systemic inflammatory response syndrome (SIRS) or SIRS-like immune disorders (63). The gene discussed is IL1B; the disease is systemic inflammatory response syndrome.