ACE2 and Alzheimer disease: In summary, a growing body of scientific evidence pointed out that the upregulation of ACE2 and an increased proportion of Ang-(1-7)/Ang II, parallel to the positive tailoring of Ang II signaling through AT2R and Ang-(1-7) through MasR, determine an improvement in cognitive function and is involved in the treatment of dementia, above all AD (Figure 2).